Feasibility of a transmucosal sublingual fentanyl tablet as a procedural pain treatment in colonoscopy patients: a prospective placebo-controlled randomized study
| Autor: | Klaus T. Olkkola, Heikki Huhtinen, P. Varpe, Nora Hagelberg, E Karru, Mari Fihlman, Teijo I. Saari |
|---|---|
| Přispěvatelé: | HUS Perioperative, Intensive Care and Pain Medicine, Department of Diagnostics and Therapeutics, Clinicum, Helsinki University Hospital Area, Anestesiologian yksikkö |
| Rok vydání: | 2020 |
| Předmět: |
Male
PHARMACOKINETICS Colonoscopy PROPOFOL Pain Procedural law.invention Fentanyl Placebos DOUBLE-BLIND 0302 clinical medicine Randomized controlled trial CONSCIOUS SEDATION law Medicine 030212 general & internal medicine Prospective Studies Multidisciplinary medicine.diagnostic_test ALFENTANIL Gastroenterology Middle Aged 3. Good health Analgesics Opioid Anesthesia SAFETY DISCOMFORT 030211 gastroenterology & hepatology Female medicine.symptom Propofol medicine.drug SPRAY Nausea Sedation Administration Sublingual Pain Placebo Article 03 medical and health sciences Medical research Double-Blind Method Humans Alfentanil Aged business.industry EFFICACY 3126 Surgery anesthesiology intensive care radiology 3121 General medicine internal medicine and other clinical medicine Feasibility Studies business |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Since patients often experience pain and unpleasantness during a colonoscopy, the present study aimed to evaluate the efficacy and safety of sublingually administered fentanyl tablets for pain treatment. Furthermore, since the use of intravenous drugs significantly increases colonoscopy costs, sublingual tablets could be a cost-effective alternative to intravenous sedation. We conducted a prospective placebo-controlled randomized study of 158 patients to evaluate the analgesic effect of a 100 µg dose of sublingual fentanyl administered before a colonoscopy. Pain, sedation, nausea, and satisfaction were assessed during the colonoscopy by the patients as well as the endoscopists and nurses. Respiratory rate and peripheral arteriolar oxygen saturation were monitored throughout the procedure. There were no differences between the fentanyl and placebo groups in any of the measured variables. The median pain intensity values, as measured using a numerical rating scale, were 4.5 in the fentanyl group and 5 in the placebo group. The sedation and oxygen saturation levels and the respiratory rate did not differ between the groups. The majority of the colonoscopies were completed.Our results indicate that a 100 µg dose of sublingual fentanyl is not beneficial compared to the placebo in the treatment of procedural pain during a colonoscopy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |