Features of intrathecal immunoglobulins in patients with multiple sclerosis
| Autor: | Franziska Di Pauli, Rainer Ehling, Claudia Gneiss, Thomas Berger, Markus Reindl, Bettina Kuenz, Florian Deisenhammer, Viktoria Gredler, Michael Schocke, Andreas Lutterotti |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Immunoglobulins Immunoglobulin E Subclass Lesion Young Adult Multiple Sclerosis Relapsing-Remitting Cerebrospinal fluid Humans Medicine B cell Cerebrospinal Fluid B-Lymphocytes biology business.industry Multiple sclerosis Middle Aged Flow Cytometry medicine.disease Magnetic Resonance Imaging Isotype medicine.anatomical_structure Neurology Immunoglobulin G Immunology biology.protein Female Neurology (clinical) Nervous System Diseases Antibody medicine.symptom business |
| Zdroj: | Journal of the Neurological Sciences. 288:147-150 |
| ISSN: | 0022-510X |
| Popis: | We have analyzed immunoglobulin (Ig) isotypes and IgG subclasses in cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and other neurological diseases to determine whether different Ig isotype patterns correlate with clinical or paraclinical findings and CSF B cell populations. Intrathecal IgG1 synthesis was elevated in MS patients. An increased intrathecal IgM production was found in patients with a higher cerebral MRI lesion burden, whereas other clinical and paraclinical parameters were not associated with a specific Ig isotype or subclass profile. Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts. |
| Databáze: | OpenAIRE |
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