Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men
| Autor: | Charnita Zeigler-Johnson, Pedro L. Fernández, Serigne Magueye Gueye, Mohamed Jalloh, Andre van der Merwe, Timothy R. Rebbeck, Elaine Spangler |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Article Subject Urology Disease lcsh:RC870-923 Population stratification lcsh:RC254-282 Metastasis 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine Genotype medicine CYP3A5 030304 developmental biology Gynecology 0303 health sciences business.industry lcsh:Diseases of the genitourinary system. Urology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 3. Good health 030220 oncology & carcinogenesis SRD5A2 Gene polymorphism business Research Article |
| Zdroj: | Prostate Cancer, Vol 2012 (2012) Prostate Cancer |
| ISSN: | 2090-312X 2090-3111 |
| Popis: | Prostate cancer is the most common cancer in men in developed countries and the leading cause of mortality in males in less developed countries. African ethnicity is one of the major risk factors for developing prostate cancer. Pathways involved in androgen metabolism have been implicated in the etiology of the disease. Analyses of clinical data andCYP3A4,CYP3A5, andSRD5A2genotypes were performed in South African White (120 cases; 134 controls), Mixed Ancestry (207 cases; 167 controls), and Black (25 cases; 20 controls) men, as well as in Senegalese men (86 cases; 300 controls). Senegalese men were diagnosed earlier with prostate cancer and had higher median PSA levels compared to South African men. Metastasis occurred more frequently in Senegalese men. Gene polymorphism frequencies differed significantly between South African and Senegalese men. TheCYP3A4rs2740574 polymorphism was associated with prostate cancer risk and tumor aggressiveness in South African men, after correction for population stratification, and theSRD5A2rs523349 CG genotype was inversely associated with high-stage disease in Senegalese men. These data suggest that variants previously associated with prostate cancer in other populations may also affect prostate cancer risk in African men. |
| Databáze: | OpenAIRE |
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