Universal screening test based on analysis of circulating organ-enriched microRNAs: a novel approach to diagnostic screening
| Autor: | Kira S. Sheinerman, Samuil R. Umansky |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Lung Diseases
Screening test Gastrointestinal Diseases Disease Bioinformatics Pathology and Forensic Medicine microRNA Genetics medicine Humans Mass Screening Diagnostic screening Molecular Biology Genetic Association Studies Organ system business.industry Early disease Cancer Neurodegenerative Diseases Genomics medicine.disease MicroRNAs Molecular Diagnostic Techniques Organ Specificity Immunology Molecular Medicine business Biomarkers |
| Zdroj: | Expert Review of Molecular Diagnostics. 15:329-338 |
| ISSN: | 1744-8352 1473-7159 |
| DOI: | 10.1586/14737159.2014.973858 |
| Popis: | Early disease detection leads to more effective and cost-efficient treatment. It is especially important for cancer and neurodegenerative diseases, because progression of these pathologies leads to significant and frequently irreversible changes in underlying pathophysiological processes. At the same time, the development of specific screening tests for detection of each of the hundreds of human pathologies in asymptomatic stage may be impractical. Here, we discuss a recently proposed concept: the development of minimally invasive Universal Screening Test (UST) based on analysis of organ-enriched microRNAs in plasma and other bodily fluids. The UST is designed to detect the presence of a pathology in particular organ systems, organs, tissues or cell types without diagnosing a specific disease. Once the pathology is detected, more specific, and if necessary invasive and expensive, tests can be administered to precisely define the nature of the disease. Here, we discuss recent studies and analyze the data supporting the UST approach. |
| Databáze: | OpenAIRE |
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