The Predictive Value of Tumor Size, Volume, and Markers During Radiation Therapy in Patients With Cervical Cancer
| Autor: | KiHoon Sung, Chan Yong Park, Hun Jung Kim, Young Sup Shim, Young Saing Kim, Young Eun Choi, Kyu Chan Lee, Seok Ho Lee, Seung Joon Choi, Jin Woo Shin, Soyi Lim, Kwang Beom Lee, Sun Jin Sym |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adult medicine.medical_specialty medicine.medical_treatment Brachytherapy Uterine Cervical Neoplasms Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Antigen Antigens Neoplasm Predictive Value of Tests Internal medicine medicine Biomarkers Tumor Humans 030212 general & internal medicine Progression-free survival Survival rate Serpins Aged Neoplasm Staging Retrospective Studies Cervical cancer Aged 80 and over business.industry Obstetrics and Gynecology Middle Aged medicine.disease Prognosis Primary tumor Radiation therapy Survival Rate 030220 oncology & carcinogenesis Predictive value of tests Female business |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 27(1) |
| ISSN: | 1525-1438 |
| Popis: | ObjectivesWe investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) in patients with cervical cancer.MethodsWe conducted a review of 40 patients treated with RT. All patients received external beam RT and intracavitary brachytherapy. The primary tumor volume and squamous cell carcinoma antigen levels were measured pre-RT and mid-RT. Overall survival (OS) and progression free survival (PFS) were estimated, and possible prognostic factors for survival were analyzed.ResultsThe correlation coefficient between primary tumor volume reduction rate (pTVRR) and serum squamous cell carcinoma antigen reduction rate in all patients was 0.550 (P < 0.001). In univariate analysis, stage more than II (P 3 or more (P = 0.05), mid-RT tumor size of 4 cm or more (P = 0.004), and pTVRR of 90% or less (P = 0.031) were significant unfavorable prognostic factors for PFS, whereas stage (P = 0.009) was the only significant prognostic factor for OS. Multivariable analysis revealed that none of these factors were independently associated with PFS or OS.ConclusionsThere was a significant correlation between pTVRR and squamous cell carcinoma antigen reduction rate. Our findings indicate that the tumor parameters such as pre-RT pTV, mid-RT tumor size, and pTVRR are associated with PFS in women with cervical cancer. |
| Databáze: | OpenAIRE |
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