A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families
| Autor: | Jenny von Salomé, Samuel Gebre-Medhin, Isabelle Henriksson, Masoud Karimi, Annika Lindblom, Erik Björck, Christos Aravidis, Kristina Lagerstedt-Robinson, Gustav Silander, Jan Erik Frödin, Marie Stenmark Askmalm, Emma Tham |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty Extracolonic congenital hereditary and neonatal diseases and abnormalities lcsh:QH426-470 MLH1 lcsh:RC254-282 Cancer syndrome 03 medical and health sciences 0302 clinical medicine Internal medicine medicine neoplasms Genetics (clinical) MMR genes Tumour spectrum Lynch syndrome Cancer och onkologi business.industry Endometrial cancer Research Cancer nutritional and metabolic diseases lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease digestive system diseases MSH6 lcsh:Genetics 030220 oncology & carcinogenesis Cancer and Oncology 030211 gastroenterology & hepatology Skin cancer business Ovarian cancer |
| Zdroj: | Hereditary Cancer in Clinical Practice Hereditary Cancer in Clinical Practice, Vol 16, Iss 1, Pp 1-11 (2018) |
| Popis: | Background Lynch Syndrome is an autosomal dominant cancer syndrome caused by pathogenic germ-line variants in one of the DNA-mismatch-repair (MMR) genes MLH1, MSH2, MSH6 or PMS2. Carriers are predisposed to colorectal and endometrial cancer, but also other cancer types. The purpose of this retrospective study was to characterize the tumour spectrum of the Swedish Lynch syndrome families. Methods Data were obtained from genetically verified 235 Lynch families from five of the six health care regions in Sweden. The material was stratified for gender, primary cancer, age and mutated gene and the relative proportions of specific cancer types were compared to those in the general population. Results A total of 1053 family members had 1493 cancer diagnoses of which 1011 were colorectal or endometrial cancer. Individuals with pathogenic variants in MLH1 and MSH2 comprised 78% of the cohort. Among the 482 non-colorectal/non-endometrial cancer diagnoses, MSH2 carriers demonstrated a significantly increased proportion of urinary tract, gastric, small bowel, ovarian and non-melanoma skin cancer compared to the normal population. MLH1 carriers had an elevated proportion of gastrointestinal cancers (gastric, small bowel, pancreas), while MSH6 carriers had more ovarian cancer than expected. Gastric cancer was predominantly noted in older generations. Conclusion Lynch syndrome confers an increased risk for multiple cancers other than colorectal and endometrial cancer. The proportions of other cancers vary between different MMR genes, with highest frequency in MSH2-carriers. Gender and age also affect the tumour spectrum, demonstrating the importance of additional environmental and constitutional parameters in determining the predisposition for different cancer types. |
| Databáze: | OpenAIRE |
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