MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease

Autor: Joel Ramirez, Melissa F. Holmes, Courtney Berezuk, Donna Kwan, Brian Tan, Derek Beaton, Christopher J.M. Scott, Miracle Ozzoude, Fuqiang Gao, Di Yu, Walter Swardfager, Jane Lawrence-Dewar, Dar Dowlatshahi, Gustavo Saposnik, Mark I. Boulos, Brian J. Murray, Sean Symons, Robert Bartha, Sandra E. Black, Richard H. Swartz, Andrew Lim, Michael Strong, Peter Kleinstiver, Natalie Rashkovan, Susan Bronskill, Michael Borrie, Elizabeth Finger, Corinne Fischer, Andrew Frank, Morris Freedman, Sanjeev Kumar, Stephen Pasternak, Bruce Pollock, Tarek Rajji, Dallas Seitz, David Tang-Wai, Carmela Tartaglia, Brenda Varriano, Agessandro Abrahao, Marvin Chum, Christen Shoesmith, John Turnbull, Lorne Zinman, Julia Fraser, Bill McIlroy, Ben Cornish, Karen Van Ooteghem, Frederico Faria, Manuel Montero-Odasso, Yanina Sarquis-Adamson, Alanna Black, Barry Greenberg, Wendy Hatch, Chris Hudson, Elena Leontieva, Ed Margolin, Efrem Mandelcorn, Faryan Tayyari, Sherif Defrawy, Don Brien, Ying Chen, Brian Coe, Doug Munoz, Alisia Bonnick, Leanne Casaubon, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, David Breen, David Grimes, Mandar Jog, Anthony Lang, Connie Marras, Mario Masellis, Tom Steeves, Dennis Bulman, Allison Ann Dilliott, Mahdi Ghani, Rob Hegele, John Robinson, Ekaterina Rogaeva, Sali Farhan, Rob Bartha, Hassan Haddad, Nuwan Nanayakkara, Christopher Scott, Melissa Holmes, Sabrina Adamo, Mojdeh Zamyadi, Stephen Arnott, Malcolm Binns, Wendy Lou, Pradeep Raamana, Stephen Strother, Kelly Sunderland, Athena Theyers, Abiramy Uthirakumaran, Guangyong (GY) Zou, Sujeevini Sujanthan, David Munoz, Roger A. Dixon, John Woulfe, Brian Levine, Paula McLaughlin, J.B. Orange, Alicia Peltsch, Angela Roberts, Angela Troyer
Rok vydání: 2021
Předmět:
Zdroj: Medical Biophysics Publications
ISSN: 1878-5506
Popis: Objectives Recent studies suggest that interindividual genetic differences in glial-dependent CSF flow through the brain parenchyma, known as glymphatic flow, may trigger compensatory changes in human sleep physiology. In animal models, brain perivascular spaces are a critical conduit for glymphatic flow. We tested the hypothesis that MRI-visible PVS volumes, a putative marker of perivascular dysfunction, are associated with compensatory differences in real-world human sleep behavior. Methods We analyzed data from 152 cerebrovascular disease patients from the Ontario Neurodegenerative Disease Research Initiative (ONDRI). PVS volumes were measured using 3T-MRI. Self-reported total sleep time, time in bed, and daytime dysfunction were extracted from the Pittsburgh Sleep Quality Index. Results Individuals with greater PVS volumes reported longer time in bed (+0.85 h per log10 proportion of intracranial volume (ICV) occupied by PVS, SE = 0.30, p = 0.006) and longer total sleep times (+0.70 h per log10 proportion of ICV occupied by PVS volume, SE = 0.33, p = 0.04), independent of vascular risk factors, sleep apnea, nocturnal sleep disturbance, depression, and global cognitive status. Further analyses suggested that the positive association between PVS volumes and total sleep time was mediated by greater time in bed. Moreover, despite having on average greater total sleep times, individuals with greater basal ganglia PVS volumes were more likely to report daytime dysfunction (OR 5.63 per log10 proportion of ICV occupied by PVS, 95% CI: 1.38–22.26, p = 0.018). Conclusions Individuals with greater PVS volumes spend more time in bed, resulting in greater total sleep time, which may represent a behavioral compensatory response to perivascular space dysfunction.
Databáze: OpenAIRE
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