The influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies
| Autor: | Norisca Aliza Putriana, Dolih Gozali, Koujirou Yamamoto, Daisuke Nagano, Taofik Rusdiana, Takuya Araki, Yanni D. Mardhiani |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
drug-herb interaction AUC Herb-Drug Interactions Pharmaceutical Science RM1-950 Multiple dose Curcuma Pharmacokinetics parasitic diseases Drug Discovery medicine Animals Rats Wistar Fluconazole Pharmacology biology Traditional medicine Dose-Response Relationship Drug business.industry Plant Extracts Warfarin Anticoagulants General Medicine biology.organism_classification Rats Curcuma xanthorrhiza Complementary and alternative medicine Indonesia Concomitant Area Under Curve Molecular Medicine Zingiberaceae Therapeutics. Pharmacology biological half-life business medicine.drug Research Article |
| Zdroj: | Pharmaceutical Biology article-version (VoR) Version of Record Pharmaceutical Biology, Vol 59, Iss 1, Pp 639-646 (2021) |
| ISSN: | 1744-5116 1388-0209 |
| Popis: | Context Co-administration between warfarin (WF) and Curcuma xanthorrhiza Roxb. (Zingiberaceae) (CX) is found in Indonesian patients and need to be evaluated. Objective This study assesses the effect of concomitant administration of CX extract on the pharmacokinetics of WF in rats. Materials and methods Wistar rats were divided into 4 groups (n = 6) and administered with 2% Pulvis Gummi Arabicum (PGA, control), fluconazole (FZ, 6 mg/kg), CX-1 (6 mg/kg) or CX-2 (18 mg/kg BW) for 7 days. For the single-dose study, at the 8th day, WF (1 mg/kg) was administered to all groups and blood samples were taken from 0.25 to 72 h. For the multiple-dose study, daily dose of WF was administered to all groups of rats and at the 7th to 9th day, the rats were treated with PGA, CX-1, CX-2 and FZ. Blood samples were withdrawn daily at 4 h after administration of WF from the 1st to 11th day. Results The area under the curve (AUC) of R- and S-WF in the CX-2 group was a significantly higher value compared to the control (77.54 vs. 35.27 mg.h/L for R-WF and 316.26 vs. 40.16 mg.h/L for S-WF; p |
| Databáze: | OpenAIRE |
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