Lymphatic drainage of the peritoneal cavity in sheep
| Autor: | Warren Chin, John B. Hay, H. Rodela, Dimitrios G. Oreopoulos, Miles G. Johnston, Nevin J. Abernethy |
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| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Physiology Efferent Thoracic duct Iodine Radioisotopes Lymphatic System Peritoneal cavity Peritoneum medicine Animals Peritoneal Cavity Sheep business.industry Lymph duct Biological Transport Serum Albumin Bovine Anatomy Kinetics Blood medicine.anatomical_structure Lymphatic system Mediastinal lymph node Female Lymph Lymph Nodes business Evans Blue |
| Zdroj: | American Journal of Physiology-Renal Physiology. 260:F353-F358 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.1991.260.3.f353 |
| Popis: | Lymphatic drainage of the peritoneal cavity has been investigated in anesthetized sheep. Studies involving intraperitoneal administration of a complex of Evans blue dye and bovine serum albumin demonstrated the existence of three anatomically distinct pathways. In the first pathway, dye is removed from the peritoneal cavity by diaphragmatic lymphatics that pass into caudal sternal lymph nodes. Efferent lymphatics from these nodes transport the material to cranial sternal lymph nodes. Efferent cranial sternal lymphatics then convey the material either directly or indirectly, via tracheal lymphatic trunks, to the right lymph duct. In the second pathway, the complex is transported from the peritoneal cavity by diaphragmatic lymphatics that pass into the caudal mediastinal lymph node. Efferent lymphatic ducts from this node transport the material to the thoracic duct. The third pathway appears to involve transport of the dye across the mesothelial lining of the abdominal viscera and removal from the interstitium by afferent visceral lymphatics. Material taken up in this manner is ultimately transported to the thoracic duct by efferent visceral lymphatics. Experiments involving measurements of lymphatic absorption of 125I-labeled human serum albumin from the peritoneal cavity indicated that, over the 6-h period studied, 4.55 +/- 1.20 and 1.43 +/- 0.56% of the injected tracer could be recovered in thoracic duct lymph and caudal mediastinal efferent lymph, respectively, and the sum of these values represented 26% of the recovered radioactivity. On the other hand, 16.95 +/- 6.93% of the injected radioactivity could be found in the blood over the same period.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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