Bilateral panuveitis following intravesical BCG immunotherapy for bladder carcinoma
| Autor: | Gurmit S. Uppal, Michael J. Tappin, Anish N. Shah, Charalambos M. Tossounis |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Mydriatics medicine.medical_treatment Prednisolone Anti-Inflammatory Agents Visual Acuity Dexamethasone Edema Panuveitis medicine Carcinoma Immunology and Allergy Humans Aged Carcinoma Transitional Cell Bladder cancer business.industry Immunotherapy medicine.disease Surgery Ophthalmology Administration Intravesical Urinary Bladder Neoplasms Optic nerve BCG Vaccine Female medicine.symptom business BCG vaccine Uveitis |
| Zdroj: | Ocular immunology and inflammation. 18(4) |
| ISSN: | 1744-5078 |
| Popis: | Purpose: To report a case of bilateral panuveitis following local treatment with Bacille Calmette-Guerin (BCG) immunotherapy for superficial bladder carcinoma.Design: Case report and literature review.Methods: A 70-year-old female presented with severe bilateral anterior chamber inflammation 5 days after intravesical BCG instillation. Despite topical steroids and mydriatics, inflammation worsened and bilateral optic nerve swelling developed.Results: Oral corticosteroids settled the ocular inflammation, and optic nerve function recovered. A trial of steroid cessation caused rebound uveitis, so she remains on maintenance doses of oral corticosteroid.Conclusions: Ocular inflammations following BCG therapy for bladder cancer are rare, and little is known about the management of such cases. This is the first report of bilateral panuveitis with optic nerve edema following such treatment. |
| Databáze: | OpenAIRE |
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