Hyperplasia of the juxtaglomerular complex with secondary aldosteronism without hypertension (Bartter's Syndrome)
| Autor: | Russell E. Randall, Marcelo Koppel, William P. Nixon, Newton C. Brackett |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Pathology
Spironolactone Kidney Function Tests urologic and male genital diseases Plasma renin activity Norepinephrine chemistry.chemical_compound Catecholamines Renin Child Aldosterone Angiotensin II Muscles General Medicine Water-Electrolyte Balance Hyperplasia Hyperaldosteronism Bartter's syndrome medicine.anatomical_structure Female Kidney Diseases medicine.medical_specialty Ammonium Chloride Adrenocorticotropic Hormone Chlorides Internal medicine Renin–angiotensin system medicine Humans Serum Albumin business.industry Body Weight Sodium Juxtaglomerular apparatus Glucose Tolerance Test Metyrapone medicine.disease Body Height Juxtaglomerular Apparatus 17-Ketosteroids Diet Bicarbonates Microscopy Electron Endocrinology chemistry Potassium Pituitary-Adrenal Function Tests business Triamterene |
| Zdroj: | The American Journal of Medicine. 44:813-819 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(68)90260-x |
| Popis: | Described herein is a ten year old Negro girl with hypertension of the juxtaglomerular complex, an associated increase in plasma renin activity and hyperaldosteronism without hypertension (Bartter's syndrome). In addition to the characteristic histologic findings previously reported by light microscopy, electron photomicrographs confirmed the presence of juxtaglomerular cell hyperplasia and an increased number of mesangial cells morphologically resembling juxtaglomerular cells without granules. The glomerular capillary basement membranes and epithelial cell foot processes appeared normal and the renal arterioles were thickened and sclerotic. Arterioles seen in a gastrocnemius muscle biopsy specimen also appeared thickened. The finding of increased plasma renin levels while the patient was on a normal sodium intake and following expansion of the extracellular fluid volume during infusions of albumin indicates a relative autonomy of the renin-angiotensin mechanism in this syndrome. Suggestions are presented within the framework of available evidence as to the pathogenesis of the disorder. |
| Databáze: | OpenAIRE |
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