Acute generalised exanthematous pustulosis: An update
| Autor: | Aarti Sarda, Abhishek De, Dayamay Pal, Projna Biswas, Sudip Kumar Das |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Drug
medicine.medical_specialty medicine.drug_class media_common.quotation_subject medicine.medical_treatment Antibiotics adverse drug reaction Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Eosinophilic lcsh:Dermatology Medicine Acute generalised exanthematous pustulosis Adverse effect IJD® Symposium media_common business.industry Incidence (epidemiology) severe cutaneous adverse reaction lcsh:RL1-803 medicine.disease pustular psoriasis 030220 oncology & carcinogenesis business Adverse drug reaction Topical steroid Rare disease |
| Zdroj: | Indian Journal of Dermatology, Vol 63, Iss 1, Pp 22-29 (2018) Indian Journal of Dermatology |
| ISSN: | 1998-3611 0019-5154 |
| Popis: | Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is attributed to drugs in more than 90% of cases. It is a rare disease, with an estimated incidence of 1-5 patients per million per year. The clinical manifestations characterised by the rapid development of sterile pustular lesions, fever and leucocytosis. Number of drugs has been reported to be associated with AGEP, most common being the antibiotics. Histopathologically there is intraepidermal pustules and papillary dermal oedema with neutrophilic and eosinophilic infiltrations. Systemic involvement can be present in more severe cases. Early diagnosis with withdrawal of the causative drug is the most important step in the management. Treatment includes supportive care, prevention of antibiotics and use of a potent topical steroid. |
| Databáze: | OpenAIRE |
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