Plasma microRNAs characterising patients with immune thrombocytopenic purpura
| Autor: | Yunxiao Zhao, Lan Dai, Bin Zuo, Changgeng Ruan, Zhen Weng, Yang He, Juping Zhai, Lifang You, Qingyu Wu, Jianfeng Yang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Blood Platelets Genetic Markers Male Microarray Down-Regulation Real-Time Polymerase Chain Reaction 03 medical and health sciences Young Adult Immune system immune system diseases hemic and lymphatic diseases microRNA Medicine Humans Aged Autoantibodies Purpura Thrombocytopenic Idiopathic business.industry Platelet Count Gene Expression Profiling Autoantibody Computational Biology Hematology Middle Aged medicine.disease Thrombocytopenic purpura Up-Regulation Gene expression profiling MicroRNAs 030104 developmental biology Real-time polymerase chain reaction Case-Control Studies Immunology Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Thrombosis and haemostasis. 117(7) |
| ISSN: | 2567-689X |
| Popis: | SummaryAltered microRNA (miRNA) expression has been reported in patients with immune thrombocytopenic purpura (ITP). However, the detailed expression profiling of cell-free circulating miRNAs in ITP patients has not been fully investigated. In this study, we aimed to examine plasma miRNAs in ITP patients and evaluate their diagnostic values. Plasma samples from 74 ITP patients and 58 healthy controls were obtained and allocated into discovery, validation, and therapy-response sets. Initial screen with a miRNA microarray assay identified 23 miRNAs with different levels between ITP patients and healthy controls (>1.5-fold changes; p |
| Databáze: | OpenAIRE |
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