Pitfalls in the laboratory assessment of serum prealbumin levels in hemato-oncological patients
| Autor: | Karin Malickova, Markéta Marková Štastná, Helena Brodska, Tomáš Zima |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Serum albumin Positive correlation Medical Oncology Gastroenterology General Biochemistry Genetics and Molecular Biology Young Adult Predictive Value of Tests Intensive care Internal medicine medicine Retrospective analysis Humans Prealbumin Serum cholesterol Whole blood Aged Retrospective Studies biology business.industry nutritional and metabolic diseases Reproducibility of Results Hematology Middle Aged medicine.disease Malnutrition Transthyretin Intensive Care Units Hematologic Neoplasms biology.protein Female business Biomarkers Blood Chemical Analysis |
| Zdroj: | Clinical laboratory. 60(11) |
| ISSN: | 1433-6510 |
| Popis: | BACKGROUND To highlight specific aspects of serum prealbumin measurements in hemato-oncological patients. METHODS Retrospective analysis of 4911 serum prealbumin measurements with special attention to values from hemato-oncological Intensive Care Units (ICU) patients. RESULTS Prealbumin serum levels in hemato-oncological ICU patients (n = 530) were significantly higher when compared to other ICU cohorts (p < 0.0001). Their prealbuminemia did not correlate with serum albumin (p = 0.104) and was not affected by serum cholesterol or triglycerides (p = 0.076 and p = 0.430, respectively). Surprisingly, serum prealbumin has shown a positive correlation with cyclosporine in whole blood levels (r = 0.269, p = 0.010). CONCLUSIONS A supposed explanation for our findings probably lies in a combination of several factors, including interference with the analysis itself and contamination or possible interference with the medication, e.g., cyclosporine. The prealbumin values do not reflect the actual nutritional state and cannot be regarded as a useful marker of malnutrition in these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|