Immunomodulating Effects Depend on Prolactin Levels in Patients with Hyperprolactinemia
Autor: | Mina Hovland, Anna Sundin, Jeanette Wahlberg, Jan Ernerudh, Sandra Hellberg, Lea Ewerman, Maria C. Jenmalm, Eva Landberg, Bertil Ekman |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Chemokine Endocrinology Diabetes and Metabolism Clinical Biochemistry Immunoglobulins 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Lymphocyte Activation Biochemistry Immunomodulation 03 medical and health sciences Th2 Cells 0302 clinical medicine Endocrinology Immune system Internal medicine medicine Humans CXCL13 B cell biology business.industry Prolactin receptor Biochemistry (medical) General Medicine Middle Aged Th1 Cells Chemokine CXCL13 Prolactin Hyperprolactinemia C-Reactive Protein medicine.anatomical_structure Case-Control Studies biology.protein Th17 Cells Female Chemokines Cell activation business Biomarkers CCL22 |
Zdroj: | Hormone and Metabolic Research. 52:228-235 |
ISSN: | 1439-4286 0018-5043 |
Popis: | Prolactin is known to have immune modulatory effects acting through the prolactin receptor, which is present on a variety of immune cells. Certain chemokines contribute to form the type of T helper (Th) preponderance in the immune response. The objective of this work was to assess if hyperprolactinemia not related to pregnancy is associated with changes in circulating levels of chemokines and other immunological markers. In this cross sectional study, 35 patients with hyperprolactinemia (5 men), and 102 healthy blood donors (19 men) were included. Serum levels of Th1- Th2- and Th17-associated chemokines, C-reactive protein, immunoglobulins, and the B cell attracting chemokine CXCL13 were assessed. The hyperprolactinemic group had significantly higher levels of Th2 associated CCL22 (p=0.022), Th17 associated CXCL1 (p=0.001), B cell attracting CXCL13 (p=0.003), and C-reactive protein (p3600 mU/l) prolactin levels. To evaluate a possible dose-associated response to prolactin, an in vitro model was used, showing prolactin-induced increase in T-helper cell activation at moderate levels, while activation decreased at higher levels. Hyperprolactinemia seems to have several immunomodulatory effects and was associated with increased levels of chemokines associated with Th2 and Th17 responses and B cell attraction. However, patients with greatly increased prolactin had normal levels of chemokines, and in vitro, high levels of prolactin decreased T-helper cell activation. |
Databáze: | OpenAIRE |
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