Is Helicobacter pylori seropositivity related to body mass index in the United States?

Autor:	N. S. Weiss, D. J. Kearney, George N. Ioannou
Rok vydání:	2005
Předmět:	Adult Leptin Male medicine.medical_specialty Population Enzyme-Linked Immunosorbent Assay Overweight Body Mass Index Helicobacter Infections Bacterial Proteins Internal medicine medicine Humans CagA Pharmacology (medical) Obesity education Aged Antigens Bacterial education.field_of_study Helicobacter pylori Hepatology biology business.industry Gastroenterology Odds ratio Middle Aged bacterial infections and mycoses biology.organism_classification medicine.disease United States Endocrinology Female medicine.symptom Epidemiologic Methods business Body mass index
Zdroj:	Alimentary Pharmacology and Therapeutics. 21:765-772
ISSN:	1365-2036 0269-2813
Popis:	Summary Background: Helicobacter pylori infection may decrease serum ghrelin and increase gastric leptin levels, which may, in turn, decrease body mass index. Aim: To determine whether H. pylori seropositivity is associated with body mass index. Methods: Serum H. pylori and cytotoxin-associated gene product A (CagA) antibody levels were measured on 6724 adult participants of the third National Health and Nutrition Examination Survey (1988–91). We evaluated the association between H. pylori/CagA antibody status [both negative (−/−), H. pylori-positive/CagA-negative (+/−), or both positive (+/+)] and body mass index, adjusting for sociodemographic factors. We also investigated whether H. pylori/cytotoxin-associated gene product A antibody status was associated with fasting serum leptin levels. Results: H. pylori/CagA antibody status was not associated with obesity (body mass index ≥ 30 kg/m2) [adjusted odds ratio (OR) 1.2, 95% CI: 0.9–1.6 comparing (+/+) to (−/−) and adjusted OR 1.1, 95% CI: 0.8–1.5 comparing (+/−) to (−/−)], overweight (body mass index 25 to
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd78bef5188785c494bb23515670af3 https://doi.org/10.1111/j.1365-2036.2005.02369.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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