Clinical and Prognostic Significance of Cerebrospinal Fluid Opening and Closing Pressures in Pediatric Pseudotumor Cerebri Syndrome
| Autor: | Grace L. Paley, Christina L. Szperka, Shannon J. Beres, Evanette Burrows, Shana E. McCormack, Chantal J. Boisvert, Marianne Chilutti, Geraldine Liu, Claire A. Sheldon, Grant T. Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Adolescent Pseudotumor cerebri Pseudotumor cerebri syndrome Neurosurgical Procedures Article 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Developmental Neuroscience Cerebrospinal Fluid Pressure Outcome Assessment Health Care medicine Humans 030212 general & internal medicine Child Papilledema Closing (morphology) Retrospective Studies Pseudotumor Cerebri business.industry Significant difference Headache Retrospective cohort study Prognosis medicine.disease Surgery Neurology Child Preschool Pediatrics Perinatology and Child Health Female Neurology (clinical) medicine.symptom business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Pediatr Neurol |
| ISSN: | 0887-8994 |
| DOI: | 10.1016/j.pediatrneurol.2018.02.011 |
| Popis: | Background The purpose of this study was to determine the prognostic utility of closing pressure and volume of cerebrospinal fluid removed with respect to papilledema resolution and headache improvement in pediatric pseudotumor cerebri syndrome. Methods This is a retrospective observational study of 93 children with definite pseudotumor cerebri syndrome. The primary outcome measure was time to resolution of papilledema, and the secondary outcome measure was time to resolution of headache. Results There were no significant differences in gender, age, or body mass index z score observed between subjects with (N = 35) and without (N = 58) documented closing pressure. The median time to resolution of papilledema was not statistically different between children above or equal to and those below the median closing pressure (170 mm of cerebrospinal fluid, n = 31, P = 0.391) or the volume of median cerebrospinal fluid removed (16 mL, n = 19, P = 0.155). There was no statistically significant difference detected in days of headache between the children with opening pressure above and equal to the median (400 mm of cerebrospinal fluid) and the children with opening pressure below the median (n = 44, P = 0.634). Conclusions No significant association between closing pressure, amount of cerebrospinal fluid removed, and time to resolution of papilledema due to pseudotumor cerebri syndrome was detected. The diagnostic and therapeutic purposes of either measuring the closing pressure or maximizing the volume of cerebrospinal fluid removed were not evident in these analyses. |
| Databáze: | OpenAIRE |
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