A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity
| Autor: | Adam Safron, Liliana Ramona Demenescu, Martin Walter, Lejla Colic, Meng Li, Coraline D. Metzger, Shijia Li, Bharat B. Biswal |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cingulate cortex Magnetic Resonance Spectroscopy Glutamine computer.software_genre physiopathology [Cerebral Cortex] Correlation chemistry.chemical_compound methods [Connectome] methods [Magnetic Resonance Imaging] 0302 clinical medicine Voxel Cortex (anatomy) Hamd Pharmacology (medical) Cerebral Cortex Glutamate receptor General Medicine Middle Aged Magnetic Resonance Imaging methods [Magnetic Resonance Spectroscopy] Psychiatry and Mental health medicine.anatomical_structure Female Psychology Adult Glutamic Acid Creatine Gyrus Cinguli 03 medical and health sciences metabolism [Gyrus Cinguli] mental disorders Connectome medicine Humans ddc:610 metabolism [Depressive Disorder Major] metabolism [Glutamine] physiopathology [Gyrus Cinguli] Biological Psychiatry metabolism [Creatine] Depressive Disorder Major metabolism [Cerebral Cortex] metabolism [Glutamic Acid] physiopathology [Depressive Disorder Major] 030227 psychiatry chemistry Insula computer Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | European Archives of Psychiatry and Clinical Neuroscience European archives of psychiatry and clinical neuroscience 267(2), 95-105 (2016). doi:10.1007/s00406-016-0726-1 |
| ISSN: | 1433-8491 0940-1334 |
| DOI: | 10.1007/s00406-016-0726-1 |
| Popis: | Abnormal anterior insula (AI) response and functional connectivity (FC) is associated with depression. In addition to clinical features, such as severity, AI FC and its metabolism further predicted therapeutic response. Abnormal FC between anterior cingulate and AI covaried with reduced glutamate level within cingulate cortex. Recently, deficient glial glutamate conversion was found in AI in major depression disorder (MDD). We therefore postulate a local glutamatergic mechanism in insula cortex of depressive patients, which is correlated with symptoms severity and itself influences AI’s network connectivity in MDD. Twenty-five MDD patients and 25 healthy controls (HC) matched on age and sex underwent resting state functional magnetic resonance imaging and magnetic resonance spectroscopy scans. To determine the role of local glutamate–glutamine complex (Glx) ratio on whole brain AI FC, we conducted regression analysis with Glx relative to creatine (Cr) ratio as factor of interest and age, sex, and voxel tissue composition as nuisance factors. We found that in MDD, but not in HC, AI Glx/Cr ratio correlated positively with AI FC to right supramarginal gyrus and negatively with AI FC toward left occipital cortex (p < 0.05 family wise error). AI Glx/Cr level was negatively correlated with HAMD score (p < 0.05) in MDD patients. We showed that the local AI ratio of glutamatergic–creatine metabolism is an underlying candidate subserving functional network disintegration of insula toward low level and supramodal integration areas, in MDD. While causality cannot directly be inferred from such correlation, our finding helps to define a multilevel network of response-predicting regions based on local metabolism and connectivity strength. |
| Databáze: | OpenAIRE |
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