Roles of Adenosine Receptor Subtypes in the Antinociceptive Effect of Intrathecal Adenosine in a Rat Formalin Test

Autor:	Jeong Il Choi, Sung Tae Chung, Seok Jai Kim, Myung Ha Yoon, Hong Beom Bae, Chang Mo Kim
Rok vydání:	2006
Předmět:	Pharmacology Analgesics Formalin Test Adenosine Chemistry Receptors Purinergic P1 Spinal level General Medicine Adenosine A3 receptor Intrathecal Adenosine receptor Rats Nociception medicine Animals Receptor Injections Spinal Pain Measurement medicine.drug
Zdroj:	Pharmacology. 78:21-26
ISSN:	1423-0313 0031-7012
DOI:	10.1159/000094762
Popis:	The contributions of adenosine receptor subtypes to antinociception produced by adenosine were determined at the spinal level. There are 4 types of adenosine receptors, namely A1, A2A, A2B and A3. The authors investigated the properties of the subtypes of spinal adenosine receptors in terms of nociceptive modulation. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 µl) into the hind paws of male Sprague-Dawley rats. After observing the effect of intrathecal adenosine during the formalin test, the effects of intrathecal adenosine A1 (CPT), A2A (CSC), A2B (alloxazine) and A3 (MRS 1220) receptor antagonists on the action of adenosine were examined. Intrathecal adenosine inhibited phase 2 flinching response without affecting phase 1 response. CPT, CSC, alloxazine and MRS 1220 antagonized the antinociceptive action of adenosine during phase 2 of the formalin test. These results suggest that spinal adenosine A1, A2A, A2B and A3 receptors may play an important role in the antinociception of adenosine in the formalin-induced facilitated state.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd2e57934573d6b3ba84613b9b38275 https://doi.org/10.1159/000094762 Zobrazit plný text záznamu