Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?
Autor: | Roberta Malaguarnera, Veronica Vella, Maria Luisa Nicolosi, Antonino Belfiore |
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Rok vydání: | 2017 |
Předmět: |
insulin
obesity medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Review Type 2 diabetes Bioinformatics lcsh:Diseases of the endocrine glands. Clinical endocrinology Autoimmune thyroiditis 03 medical and health sciences Endocrinology 0302 clinical medicine Insulin resistance insulin resistance Internal medicine thyroid cancer medicine Hyperinsulinemia Thyroid cancer lcsh:RC648-665 business.industry Insulin medicine.disease Obesity insulin sensitizers Diabetes and Metabolism insulin growth factor 030220 oncology & carcinogenesis Insulin growth factor Insulin sensitizers Metformin type 2 diabetes Metabolic syndrome metformin business |
Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 8 (2017) |
ISSN: | 1664-2392 |
Popis: | In the past few decades, the incidence of thyroid cancer (TC), namely of its papillary hystotype (PTC), has shown a steady increase worldwide, which has been attributed at least in part to the increasing diagnosis of early stage tumors. However, some evidence suggests that environmental and lifestyle factors can also play a role. Among the potential risk factors involved in the changing epidemiology of TC, particular attention has been drawn to insulin-resistance and related metabolic disorders, such as obesity, type 2 diabetes, and metabolic syndrome, which have been also rapidly increasing worldwide due to widespread dietary and lifestyle changes. In accordance with this possibility, various epidemiological studies have indeed gathered substantial evidence that insulin resistance-related metabolic disorders might be associated with an increased TC risk either through hyperinsulinemia or by affecting other TC risk factors including iodine deficiency, elevated thyroid stimulating hormone, estrogen-dependent signaling, chronic autoimmune thyroiditis, and others. This review summarizes the current literature evaluating the relationship between metabolic disorders characterized by insulin resistance and the risk for TC as well as the possible underlying mechanisms. The potential implications of such association in TC prevention and therapy are discussed. |
Databáze: | OpenAIRE |
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