Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies
| Autor: | Claire M. Marchetta, Becky L. Tsang, Heather C. Hamner, Owen Devine, Yan Ping Qi, Joseph Mulinare, Jorge Rosenthal, Krista S. Crider, Jing Guo, Robert J. Berry, Amy M Cordero, Patricia Mersereau |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Adolescent Databases Factual Physiology lcsh:TX341-641 Article Young Adult Folic Acid medicine Humans Folate intake Neural Tube Defects Fortified Food Child RBC folate Randomized Controlled Trials as Topic Nutrition and Dietetics serum/plasma folate Neural tube defect business.industry Blood folate Nutritional Requirements food and beverages Bayes Theorem Middle Aged medicine.disease Observational Studies as Topic Red blood cell Nutrition Assessment medicine.anatomical_structure Biochemistry Natural food Meta-analysis Female Observational study food folate business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 7 Issue 4 Pages 2663-2686 Nutrients, Vol 7, Iss 4, Pp 2663-2686 (2015) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu7042663 |
| Popis: | Folate is found naturally in foods or as synthetic folic acid in dietary supplements and fortified foods. Adequate periconceptional folic acid intake can prevent neural tube defects. Folate intake impacts blood folate concentration however, the dose-response between natural food folate and blood folate concentrations has not been well described. We estimated this association among healthy females. A systematic literature review identified studies (1 1992–3 2014) with both natural food folate intake alone and blood folate concentration among females aged 12–49 years. Bayesian methods were used to estimate regression model parameters describing the association between natural food folate intake and subsequent blood folate concentration. Seven controlled trials and 29 observational studies met the inclusion criteria. For the six studies using microbiologic assay (MA) included in the meta-analysis, we estimate that a 6% (95% Credible Interval (CrI): 4%, 9%) increase in red blood cell (RBC) folate concentration and a 7% (95% CrI: 1%, 12%) increase in serum/plasma folate concentration can occur for every 10% increase in natural food folate intake. Using modeled results, we estimate that a natural food folate intake of ≥450 μg dietary folate equivalents (DFE)/day could achieve the lower bound of an RBC folate concentration (~1050 nmol/L) associated with the lowest risk of a neural tube defect. Natural food folate intake affects blood folate concentration and adequate intakes could help women achieve a RBC folate concentration associated with a risk of 6 neural tube defects/10,000 live births. |
| Databáze: | OpenAIRE |
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