Selected Features of Nonendocrine Pancreatic Cancer
| Autor: | Jules E. Harris, Ken M. Anderson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Cell growth Gene Expression Biology medicine.disease General Biochemistry Genetics and Molecular Biology Cellular suicide Pancreatic Neoplasms 03 medical and health sciences 0302 clinical medicine Transformed cell Karyotyping 030220 oncology & carcinogenesis Pancreatic cancer Complementary DNA Spin trap Gene expression medicine Cancer research Animals Humans 030211 gastroenterology & hepatology Carcinoma Pancreatic Ductal Programmed death |
| Zdroj: | Experimental Biology and Medicine. 226:521-537 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.1177/153537020122600604 |
| Popis: | We survey some interesting features of gene expression in non-endocrine pancreatic cancer, the response to some less widely known agents as they impact on pancreatic cell proliferation and programmed death, and several developing approaches to therapy. The proliferative and cellular suicide responses of Panc-1 cells to the free radical spin trap, NTBN, and to the 5-lipoxygenease inhibitor, MK 886, the latter assessed with CLONTECH Atlas Human cDNA Array 1, are reviewed. Difficulties in identifying those factors whose suppression or augmentation could result in inhibition of malignantly transformed cell properties are considered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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