Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
| Autor: | Fiona Byrne, Rodger Duffin, Ken Donaldson, Yurii Gounko, Gemma-Louise Davies, Adriele Prina-Mello, Yuri Volkov, Craig A. Poland, J. M. D. Coey, Wan-Seob Cho, Fiona Murphy |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Materials science Biomedical Engineering Nanowire chemistry.chemical_element 02 engineering and technology Toxicology Mice 03 medical and health sciences Peritoneal cavity Nickel Fibrosis medicine Animals Macrophage Lung Peritoneal Cavity 030304 developmental biology 0303 health sciences Nanowires Hazard potential 021001 nanoscience & nanotechnology medicine.disease Pathogenicity Mice Inbred C57BL medicine.anatomical_structure chemistry Lung aspiration Biophysics Female 0210 nano-technology |
| Zdroj: | Nanotoxicology |
| ISSN: | 1743-5404 1743-5390 |
| DOI: | 10.3109/17435390.2011.626535 |
| Popis: | The use of fibre-shaped nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of fibrous nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 mm) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short ( |
| Databáze: | OpenAIRE |
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