Second primary breast cancer after unilateral mastectomy alone or with contralateral prophylactic mastectomy
Autor: | Cindy B. Matsen, Lisa Pappas, Jayant P. Agarwal, Shailesh Agarwal |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Cancer Research Time Factors Databases Factual 0302 clinical medicine contralateral prophylactic mastectomy Epidemiology Medicine Cumulative incidence skin and connective tissue diseases Mastectomy Original Research Aged 80 and over Incidence (epidemiology) Incidence Carcinoma Ductal Breast Neoplasms Second Primary Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ductal Breast Carcinoma Treatment Outcome Oncology 030220 oncology & carcinogenesis Female Adult medicine.medical_specialty Adolescent Context (language use) survival lcsh:RC254-282 Unilateral mastectomy 03 medical and health sciences Young Adult Breast cancer Contralateral Prophylactic Mastectomy breast cancer Unilateral Breast Neoplasms Humans Radiology Nuclear Medicine and imaging Aged business.industry unilateral mastectomy Clinical Cancer Research medicine.disease United States Surgery SEER 030104 developmental biology Prophylactic Mastectomy CPM business SEER Program |
Zdroj: | Cancer Medicine, Vol 9, Iss 21, Pp 8043-8052 (2020) Cancer Medicine |
ISSN: | 2045-7634 |
Popis: | Background An increasing number of patients undergo contralateral prophylactic mastectomy (CPM) for unilateral breast cancer. However, the benefit of CPM has not been quantified in the setting of contemporary breast cancer therapy. Methods We performed an analysis of 180 068 patients in the Surveillance, Epidemiology, and End Results (SEER) database, diagnosed with unilateral ductal breast carcinoma between 1998 and 2013 and treated with unilateral mastectomy (UM) or CPM. UM was performed in 146 213 patients (81.2%); CPM was performed in 33 855 patients (19.8%). Primary outcome of interest was cumulative incidence of a second primary breast cancer in the ipsilateral or contralateral breast greater than 3 months after initial diagnosis. Cumulative incidence analysis was based on a Cox proportional model to generate curves of second primary breast cancer in any breast, ipsilateral breast only, or contralateral breast only. Results Patients who underwent CPM had a significantly reduced incidence of second primary breast cancer 10 and 15 years after surgery (CPM 0.93% [0.73%, 1.12%] vs UM 4.44% [4.28%, 4.60%]). Patients who underwent CPM had significantly lower adjusted hazard of second primary breast cancer when compared with UM (HR 0.38 vs 1.0, P We examine second primary breast cancer in the setting of unilateral or bilateral mastectomy using a population‐level database. Our results show that although patients with bilateral mastectomy have reduced odds of second primary breast cancer, this must be interpreted in the context of an overall low rate of second primary breast cancer. |
Databáze: | OpenAIRE |
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