Second primary breast cancer after unilateral mastectomy alone or with contralateral prophylactic mastectomy

Autor: Cindy B. Matsen, Lisa Pappas, Jayant P. Agarwal, Shailesh Agarwal
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Cancer Research
Time Factors
Databases
Factual
0302 clinical medicine
contralateral prophylactic mastectomy
Epidemiology
Medicine
Cumulative incidence
skin and connective tissue diseases
Mastectomy
Original Research
Aged
80 and over
Incidence (epidemiology)
Incidence
Carcinoma
Ductal
Breast
Neoplasms
Second Primary
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Ductal Breast Carcinoma
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Female
Adult
medicine.medical_specialty
Adolescent
Context (language use)
survival
lcsh:RC254-282
Unilateral mastectomy
03 medical and health sciences
Young Adult
Breast cancer
Contralateral Prophylactic Mastectomy
breast cancer
Unilateral Breast Neoplasms
Humans
Radiology
Nuclear Medicine and imaging
Aged
business.industry
unilateral mastectomy
Clinical Cancer Research
medicine.disease
United States
Surgery
SEER
030104 developmental biology
Prophylactic Mastectomy
CPM
business
SEER Program
Zdroj: Cancer Medicine, Vol 9, Iss 21, Pp 8043-8052 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Background An increasing number of patients undergo contralateral prophylactic mastectomy (CPM) for unilateral breast cancer. However, the benefit of CPM has not been quantified in the setting of contemporary breast cancer therapy. Methods We performed an analysis of 180 068 patients in the Surveillance, Epidemiology, and End Results (SEER) database, diagnosed with unilateral ductal breast carcinoma between 1998 and 2013 and treated with unilateral mastectomy (UM) or CPM. UM was performed in 146 213 patients (81.2%); CPM was performed in 33 855 patients (19.8%). Primary outcome of interest was cumulative incidence of a second primary breast cancer in the ipsilateral or contralateral breast greater than 3 months after initial diagnosis. Cumulative incidence analysis was based on a Cox proportional model to generate curves of second primary breast cancer in any breast, ipsilateral breast only, or contralateral breast only. Results Patients who underwent CPM had a significantly reduced incidence of second primary breast cancer 10 and 15 years after surgery (CPM 0.93% [0.73%, 1.12%] vs UM 4.44% [4.28%, 4.60%]). Patients who underwent CPM had significantly lower adjusted hazard of second primary breast cancer when compared with UM (HR 0.38 vs 1.0, P
We examine second primary breast cancer in the setting of unilateral or bilateral mastectomy using a population‐level database. Our results show that although patients with bilateral mastectomy have reduced odds of second primary breast cancer, this must be interpreted in the context of an overall low rate of second primary breast cancer.
Databáze: OpenAIRE
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