Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants
| Autor: | G. William Letson, David S Krause, Charlotte Gardea, Stephen B. Lambert, Thomas K Welty, Craig N. Shapiro, Harold S. Margolis, Deborah Kuehn |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pediatrics
medicine.medical_specialty Hepatitis B vaccine Hepatitis A vaccine Hepatitis A Antibodies law.invention Randomized controlled trial law Immunity medicine Humans Hepatitis A Vaccines biology business.industry Immunogenicity Age Factors Infant Vaccination Pediatrics Perinatology and Child Health Immunology biology.protein Viral disease Antibody business Immunity Maternally-Acquired Hepatitis A Virus Human |
| Zdroj: | The Journal of Pediatrics. 144:327-332 |
| ISSN: | 0022-3476 |
| Popis: | Objective To determine the effect of maternal antibody on hepatitis A vaccine immunogenicity in infants. Study design Infants of mothers negative for antibody to hepatitis A virus (anti-HAV; group 1) were administered hepatitis A vaccine at 2, 4, and 6 months of age, and infants of anti-HAV–positive mothers were randomized to receive either hepatitis A vaccine (group 2) or hepatitis B vaccine (group 3) on the same schedule. Group 3 infants subsequently received hepatitis A vaccine at 8 and 10 months of age. Results At 15 months of age, 100% of infants in group 1, 93% in group 2, and 92% in group 3 had protective levels of antibody. However, there were significant differences in the geometric mean concentration (GMC) of anti-HAV between groups. Group 1 GMC was 231 mIU/mL, compared with 85 mIU/mL for group 2 and 84 mIU/mL for group 3 (P Conclusions Passively acquired maternal anti-HAV resulted in a significantly lower final antibody response when infants were administered hepatitis A vaccine at 2, 4, and 6 months of age or at 8 and 10 months of age. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect