Glucose Turnover and Recycling in Colorectal Carcinoma
| Autor: | Ivan D. A. Johnston, Peter D. Wright, William A. Kokal, Allan Mcculloch |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Colorectal cancer Carbohydrate metabolism Weight loss Internal medicine Diabetes mellitus medicine Humans Endocrine system In patient Glucose turnover Aged Neoplasm Staging Rectal Neoplasms business.industry Middle Aged medicine.disease humanities Endocrinology Colonic Neoplasms Abnormal Liver Function Test Female Surgery medicine.symptom business Research Article |
| Zdroj: | Annals of Surgery. 198:601-604 |
| ISSN: | 0003-4932 |
| DOI: | 10.1097/00000658-198311000-00007 |
| Popis: | Glucose metabolism is affected by various pathologic states including tumors. In this project, glucose turnover and recycling rates in 11 patients with colorectal carcinoma were measured using a double-labelled 3-3H and 1-14C glucose injection technique. Fasting blood glucose, lactate, pyruvate, alanine, glycerol, 3-hydroxybutyrate, acetoacetate, plasma cortisol, and plasma insulin concentrations were also measured. No patient in the study had a history of diabetes mellitus or endocrine disorders, nor any abnormal liver function tests. The findings demonstrated a significantly elevated glucose turnover rate in patients with Dukes C and D lesions in comparison to patients with Dukes B lesions. Cori recycling rates were not significantly different between Dukes B vs. Dukes C and D patients. There were no differences between Dukes B and Dukes C and D patients in any of the metabolites measured. Furthermore, there were no significant differences in glucose turnover or recycling rates as a function of pre-illness weight loss. These data suggest that, when colorectal carcinoma extends beyond the limits of the bowel wall, glucose metabolism is significantly altered. |
| Databáze: | OpenAIRE |
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