| Popis: |
The anti-inflammatory effects of Buchholzia coriacea ethanol leaf-extract, aqueous and ethylacetate fractions in Freund’s adjuvant-induced rheumatoid arthritic albino rats were investigated. The phytochemical constituents of the extract and fractions were analyzed using standard methods. A total of 216 albino rats were used for this study. Rats used for acute toxicity using Lorke method were 36, while 180 rats were randomly divided into 12 groups, each containing 15 rats for the sub-acute study. Group 1 served as normal control. Rheumatoid arthritis was induced in groups 2 to 12 by intradermal administration of 0.1 ml complete Freund’s adjuvant into the left hind paws of the albino rats. Group 2 (positive control) received normal saline while group 3 (standard control) received 5 mg/Kg indomethacinTM (standard drug). Groups 4 to 12 were given ethanol leaf-extract, aqueous and ethylacetate fractions of Buchholzia coriacea at doses of 200, 400 and 800 mg/Kg body weight via oral intubation for 31 days. The inflammatory parameters were measured by standard laboratory procedures. Phytochemical constituents (mg/100g) in all samples were in the order of: Terpenoids>phenols>alkaloids>flavonoids>tannins>saponins>steroids>glycosides. Some phytochemicals were significantly (P Key words: Rheumatoid arthritis, Buchholzia coriacea, inflammation, anti-inflammatory. |
