A J-aggregated nanoporphyrin overcoming phototoxic side effects in superior phototherapy with two-pronged effects
| Autor: | Mengyao Yang, Xingshu Li, Gyoungmi Kim, Rui Wang, Seong-Jin Hong, Chang-Hee Lee, Juyoung Yoon |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Chemical Science. 13:12738-12746 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/d2sc04873f |
| Popis: | Phototherapy has been a promising therapeutic modality for pathological tissue due to its spatiotemporal selectivity and non-invasive characteristics. However, as a core component of phototherapy, a single photosensitizer (PS) nanoplatform integrating excellent therapeutic efficiency and minimal side effects remains an urgent but unmet need. Here, we construct a J-aggregated nano-porphyrin termed MTE based on the self-assembly of methyl-pheophorbide a derivative MPa-TEG (MT) and natural polyphenolic compound epigallocatechin gallate (EGCG). Due to the synergistic interaction between similar large π-conjugated structural EGCG and MT, MTE with small and uniform size is obtained by effectively hindering Ostwald ripening of MT. Noteworthily, MTE not only effectively avoids the inadvertent side effects of phototoxicity during transport thank to the ability of reactive oxygen species (ROS) scavenging, but also achieves two-pathway augmented superior phototherapy: (1) enhancing photodynamic therapy (PDT) |
| Databáze: | OpenAIRE |
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