Haemolysis during in vitro CO2 removal from human blood using a membrane lung
| Autor: | Keith L. Dorrington, K.M. McRae |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Membrane oxygenator Biophysics Hemolysis Artificial lung chemistry.chemical_compound medicine Humans Lung Acid-Base Equilibrium Chromatography Chemistry Sodium Membranes Artificial Carbon Dioxide Middle Aged medicine.disease Haemolysis In vitro medicine.anatomical_structure Hematocrit Carbon dioxide Immunology Potassium Female Hemoglobinemia Artificial Organs |
| Popis: | Haemolysis of human blood has been examined in vitro as a function of pH in the range 7.2–8.0. The hydrogen ion concentration of freshly donated blood from 11 donors was manipulated in 42 experiments, entirely by altering the carbon dioxide fraction of air with which the blood was equilibrated using a membrane lung. In contrast to the known alkalaemic haemolysis which occurs in canine blood, we observed no correlation between plasma haemoglobin concentrations and blood pH. We conclude that alkalaemic haemolysis is unlikely to complicate the clinical application of extracorporeal carbon dioxide removal in the management of acute respiratory failure. |
| Databáze: | OpenAIRE |
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