Increased use of antibiotics in patients treated with clozapine
| Autor: | Jimmi Nielsen, Jonathan M. Meyer, Leslie Foldager |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Antibiotics Pharmacotherapy International Classification of Diseases Internal medicine medicine Humans Pharmacology (medical) In patient Adverse effect Clozapine Biological Psychiatry Proportional Hazards Models Retrospective Studies Pharmacology Proportional hazards model business.industry medicine.disease Databases Bibliographic Anti-Bacterial Agents Psychiatry and Mental health Pneumonia Prescriptions Neurology Schizophrenia Anesthesia Neurology (clinical) Drug Monitoring business medicine.drug Agranulocytosis Antipsychotic Agents |
| Zdroj: | Nielsen, J, Foldager, L & Meyer, J M 2009, ' Increased use of antibiotics in patients treated with clozapine ', European Neuropsychopharmacology, vol. 19, no. 7, pp. 483-486 . Aarhus University |
| Popis: | Clozapine has the potential to cause agranulocytosis and an association to an increased risk of infections has been suggested. Patients with an ICD-10 F20.x were identified from the Danish Central Psychiatric Research Registry and were linked to the national prescription database to identify schizophrenia patients treated with clozapine from 1996 to 2005(N=3374). Binomial regression and Cox proportional hazards models were used. An increased use of antibiotics was found RR=1.43, CI: 1.26-1.61, P0.0001 and HR 1.14, 95% CI: 1.05-1.24, P=0.0025 with binomial regression and Cox proportional hazard model, respectively. The exact mechanism for the increased risk remains unknown, but the increased risk might be due to aspiration pneumonia caused by hypersalivation and the sedating properties of clozapine. The findings reported here should alert clinicians to be mindful of infectious processes as yet another possible somatic manifestation of clozapine treatment. |
| Databáze: | OpenAIRE |
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