Optimizing typhoid fever case definitions by combining serological tests in a large population study in Hechi City, China
| Autor: | E. Shin, Claudia M. Galindo, John D. Clemens, Anne-Laure Page, J. K. Park, D.R. Kim, Jin Yang, Lorenz von Seidlein, Camilo J. Acosta, Zhi-Yi Xu, Bai-qing Dong, Mingzhai Wang, R. L. Ochiai, Mohammad Ali |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Serotype China medicine.medical_specialty Adolescent Epidemiology Widal test Large population Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Typhoid fever Serology Agglutination Tests Internal medicine medicine Humans Blood culture Typhoid Fever Child Disease burden medicine.diagnostic_test business.industry Middle Aged medicine.disease Infectious Diseases Child Preschool Immunology business Research Article |
| Zdroj: | Epidemiology and Infection. 135:1014-1020 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268806007801 |
| Popis: | SUMMARYBlood culture-based diagnosis can only detect a fraction of the total burden ofSalmonella entericasubsp.entericaserovar Typhi. The objective of the study was to detect additional typhoid fever cases through serological tests. A total of 1732 prolonged fever episodes were evaluated using three serological tests, Widal, Tubex®and Typhidot-M®in a typhoid fever endemic area of southern China. A case definition which included a positive Widal test (TO⩾80 & TH>A), a positive Tubex®test (⩾4) and a positive Typhidot-M®test, increased the detection of cases by more than twofold from 13 to 28 cases. The case definition has a specificity of 100% and a sensitivity of 39%. Case definitions based on combinations of serological tests can detect additional typhoid fever cases with higher specificity than a single serological test. Improved case detection is essential to understand the true disease burden and can help to boost the power of intervention trials. |
| Databáze: | OpenAIRE |
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