Ribonuclease Activities and Distribution in Alzheimer's and Control Brains
| Autor: | Marcelle Morrison-Bogorad, L. W. Jennings, K. Maschhoff, Charles L. White |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Cerebellum Alkalies Biology Biochemistry Cellular and Molecular Neuroscience Ribonucleases Degenerative disease Alzheimer Disease Reference Values Internal medicine medicine Humans Tissue Distribution Ribonuclease Senile plaques chemistry.chemical_classification Temporal cortex Brain medicine.disease Temporal Lobe Enzyme assay Endocrinology Enzyme medicine.anatomical_structure chemistry biology.protein Alzheimer's disease Acids Subcellular Fractions |
| Zdroj: | Journal of Neurochemistry. 52:1071-1078 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1989.tb01849.x |
| Popis: | Levels of free and total alkaline ribonuclease, and levels of acidic ribonuclease, were measured postmortem in control brains and in the brains of patients with Alzheimer's disease. In each brain region assayed, whether control or Alzheimer's, there was a statistically significant difference between the levels of free and total alkaline ribonuclease. Between 59 and 90% of the enzyme activity was associated with alkaline ribonuclease inhibitor in an inactive complex. Levels of free and total alkaline ribonuclease varied widely among different brains and brain regions, and were always lower in cerebellum than in temporal cortex and occipital pole. There was no significant difference in the levels of total alkaline ribonuclease, free alkaline ribonuclease, or acidic ribonu-cleases between corresponding regions of Alzheimer's and control brains. There was also no qualitative difference in the subcellular distribution of the alkaline and acidic ribonucleases between Alzheimer's and control brain. No significant relationships were found between ribonuclease levels and age, neuritic plaque density, postmortem interval, or storage time. |
| Databáze: | OpenAIRE |
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