Bacterial sensing, cell signaling, and modulation of the immune response during sepsis
| Autor: | Giovana Lotici Baggio-Zappia, Chris Galanos, Marjorie Marini Rapozo, Milena Karina Coló Brunialti, Marina A. Freudenberg, Reinaldo Salomão |
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| Rok vydání: | 2012 |
| Předmět: |
Lipopolysaccharides
Cell signaling Lipopolysaccharide Gene Expression Biology Critical Care and Intensive Care Medicine Monocytes Sepsis chemistry.chemical_compound Mice Immune system Gram-Negative Bacteria medicine Animals Humans Lymphocytes Toll-like receptor Immunity Cellular Innate immune system medicine.disease Systemic inflammatory response syndrome Toll-Like Receptor 4 chemistry Immunology Host-Pathogen Interactions Emergency Medicine TLR4 Leukocytes Mononuclear Cytokines Gram-Negative Bacterial Infections Signal Transduction |
| Zdroj: | Shock (Augusta, Ga.). 38(3) |
| ISSN: | 1540-0514 |
| Popis: | Since the definition of systemic inflammatory response syndrome/sepsis was originally proposed, a large amount of new information has been generated showing a much more complex scenario of inflammatory and counterinflammatory responses during sepsis. Moreover, some fundamental mechanisms of sensing and destroying invading microorganisms have been uncovered, which include the discovery of TLR4 as the lipopolysaccharide (LPS) gene, implications of innate immune cells as drivers of the adaptive response to infection, and the modulation of multiple accessory molecules that stimulate or inhibit monocyte/macrophage and lymphocyte interactions. The complexity of the infection/injury-induced immune response could be better appreciated with the application of genomics and proteomics studies, and LPS was a useful tool in many of these studies. In this review, we discuss aspects of bacterial recognition and induced cellular activation during sepsis. Because of the relevance of endotoxin (LPS) research in the field, we focus on LPS and host interactions as a clue to understand microorganisms sensing and cell signaling, then we discuss how this response is modulated in septic patients. |
| Databáze: | OpenAIRE |
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