Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases

Autor: Remi Villenave, Bart Keijser, Pieter S. Hiemstra, Anne M. van der Does, Gimano D. Amatngalim
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Immunology
Biomedical Innovation
lcsh:Medicine
Review
Disease
Gut flora
Cystic fibrosis
digestive system
chronic inflammatory lung diseases
cystic fibrosis
03 medical and health sciences
fluids and secretions
SDG 3 - Good Health and Well-being
Life
Drug Discovery
medicine
microbiota
COPD
Pharmacology (medical)
Respiratory system
Nutrition
Pharmacology
Lung
biology
Microbiota
lcsh:R
Chronic inflammatory lung diseases
Host defence peptides
host defence peptides
biology.organism_classification
medicine.disease
Asthma
3. Good health
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Infectious Diseases
MSB - Microbiology and Systems Biology
Host-microbiota interactions
host-microbiota interactions
ELSS - Earth
Life and Social Sciences
Dysbiosis
Healthy Living
Homeostasis
Respiratory tract
Zdroj: Vaccines, Vol 6, Iss 3, p 49 (2018)
Vaccines
Vaccines, 6(3). Multidisciplinary Digital Publishing Institute
Vaccines, 6(3)
van der Does, A M, Amatngalim, G D, Keijser, B, Hiemstra, P S & Villenave, R 2018, ' Contribution of host defence proteins and peptides to host-microbiota interactions in chronic inflammatory lung diseases ', Vaccines, vol. 6, no. 3, 49 . https://doi.org/10.3390/vaccines6030049
Vaccines, 3, 6
ISSN: 2076-393X
Popis: The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of novel therapeutic strategies aimed at restoring host-microbiota homeostasis. In this review, we discuss recent literature on host-microbiota interactions in the respiratory tract, with a specific focus on the influence of endogenous host defence peptides and proteins (HDPs) on the composition of microbiota populations in vivo and explore possible HDPs-related therapeutic approaches targeting microbiota dysbiosis in chronic inflammatory lung diseases.
Databáze: OpenAIRE
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