Total Synthesis of Arylomycin A2, a Signal Peptidase I (SPase I) Inhibitor

Autor:	Jeremy Dufour, Jieping Zhu, Luc Neuville
Přispěvatelé:	Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Suzuki coupling reaction (intramol Suzuki-Miyaura total synthesis of signal peptidase I inhibitor arylomycin A2 via intramol. Suzuki-Miyaura reaction) Macrocyclization (total synthesis of signal peptidase I inhibitor arylomycin A2 via intramol. Suzuki-Miyaura reaction) biology 010405 organic chemistry Stereochemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Total synthesis Peptide 010402 general chemistry Signal peptidase I 01 natural sciences arylomycin A2 signal peptidase I inhibitor total synthesis tripeptide prepn intramol Suzuki Miyaura macrocyclization 3. Good health 0104 chemical sciences chemistry biology.protein Arylomycin A2 ComputingMilieux_MISCELLANEOUS
Zdroj:	SYNLETT SYNLETT, Georg Thieme Verlag, 2008, pp.2355-2359. ⟨10.1055/s-2008-1078209⟩
ISSN:	0936-5214 1437-2096
DOI:	10.1055/s-2008-1078209⟩
Popis:	A concise total synthesis of arylomycin A2 was accomplished featuring a key intramol. Suzuki-Miyaura reaction for the formation of the 14-membered meta,meta-cyclophane and direct coupling of a fully elaborated peptide side-chain with the macrocyclic core. [on SciFinder (R)]
Databáze:	OpenAIRE
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