Interrelationship of plasma triglycerides and HDL size and composition in rats fed different dietary saturated fats
| Autor: | Michael Lefevre, John B. Lasekan, Denise M. Ney, Hui-Chuan Lai |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Very low-density lipoprotein medicine.medical_specialty food.ingredient Chromatography Gas Saturated fat Medicine (miscellaneous) chemistry.chemical_compound food Apolipoproteins E Internal medicine Cholesterylester transfer protein medicine Animals Food science Particle Size Apolipoproteins A Triglycerides Nutrition and Dietetics Triglyceride biology Cholesterol Coconut oil Body Weight Fatty Acids Rats Inbred Strains Fasting Organ Size Lipid Metabolism Dietary Fats Rats Endocrinology chemistry Liver Saturated fatty acid biology.protein lipids (amino acids peptides and proteins) Digestion Lipoproteins HDL Corn oil |
| Zdroj: | The Journal of nutrition. 121(9) |
| ISSN: | 0022-3166 |
| Popis: | We investigated the relative effects of different dietary saturated fats on the size distribution, apolipoprotein (apo) and chemical composition of HDL in fasted rats. Male Sprague-Dawley rats (174 +/- 2 g) were fed diets containing 0.035% cholesterol and 16% fat (wt/wt) from corn oil (CO diet) or from 2% CO plus 14% butterfat (BF diet), beef tallow (BT diet), palm oil (PO diet) or coconut oil (CN diet) for 6 wk. Apparent lipid digestibility was significantly lower with the PO and BT diets vs. the CO, BF and CN diets. Plasma total cholesterol levels were significantly higher in rats fed the PO and BT diets than in rats fed the BF and CN diets but were not different among the PO-, BT- and CO-fed groups. Nondenaturing gradient gel electrophoresis immunoblot analysis indicated that HDL apo A-I and E resided on particles with significantly smaller modal diameters in rats fed all saturated fats compared with those fed the CO diet. Chemical analyses indicated that HDL generally contained proportionately less protein and more triglyceride, free cholesterol and apo E with saturated fat feeding than with CO diet feeding. Significantly higher plasma and VLDL triglyceride levels were noted with ingestion of the BT, PO or CN diet than with the CO diet. Butterfat feeding resulted in lower plasma triglycerides and HDL-esterified cholesterol than did feeding the other saturated fats. Very low density lipoprotein triglyceride concentrations were inversely correlated with HDL modal diameter of apo E containing lipoproteins (P less than 0.005). These data provide further evidence of the interrelationship of triglyceride and HDL metabolism and suggest that mechanisms independent of cholesterol ester transfer protein may mediate this response in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|