Naloxone and [Met5]enkephalin effects on retention: attenuation by adrenal denervation
| Autor: | James L. McGaugh, Shi-yi Zhang, Ronald G. Juler, Ines B. Introini-Collison |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Enkephalin Enkephalin Methionine Endogeny (+)-Naloxone Inhibitory postsynaptic potential Discrimination Learning Mice Memory Internal medicine Adrenal Glands Avoidance Learning polycyclic compounds medicine Animals Pharmacology Denervation Naloxone Chemistry Narcotic antagonist digestive oral and skin physiology Endocrinology medicine.anatomical_structure nervous system Adrenal medulla hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | European Journal of Pharmacology. 138:37-44 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(87)90334-7 |
| Popis: | This study investigated the effect of posttraining administration (i.p.) of naloxone and [Met5]enkephalin on retention in intact and adrenal-denervated mice. Naloxone (0.3 mg/kg) enhanced and [Met5]enkephalin (0.5 or 2.0 micrograms/kg) impaired retention in both inhibitory avoidance and Y-maze discrimination tasks. Further, [Met5]enkephalin antagonized the facilitative effect of naloxone on retention while naloxone attenuated the retention deficit produced by [Met5]enkephalin. However, neither naloxone nor [Met5]enkephalin affected retention in adrenal denervated mice. These findings suggest that endogenous hormones of the adrenal medulla, including [Met5]enkephalin, may be involved in the modulating influence of opiate peptides on memory storage. |
| Databáze: | OpenAIRE |
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