The discovery of hypoglycaemic sulphonamides – Montpellier, 1942
| Autor: | Thierry Lavabre-Bertrand, Jean-Luc Faillie |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Sulfonamides medicine.medical_specialty business.industry Sulfonamide (medicine) medicine.disease Hypoglycemia Typhoid fever Diabetes Mellitus Type 2 Infectious diseases department Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Hypoglycemic Agents Insulin Local environment Endocrine system Pharmacology (medical) Insulin secretion business medicine.drug |
| Zdroj: | Therapies. 76:559-566 |
| ISSN: | 0040-5957 |
| DOI: | 10.1016/j.therap.2021.09.003 |
| Popis: | Summary The pathophysiological study of diabetes mellitus took an important place in the school of Montpellier since the end of the XIXth century with Emmanuel Hedon's (1863–1933) contribution to the demonstration of the endocrine function of the pancreas. In 1942, a new sulfonamide compound (2254RP) was tested in the infectious diseases department of Pr M. Janbon (1898–1996) on cases of typhoid fever, leading to several deaths rapidly related to hypoglycaemia. The physiologist Auguste Loubatieres (1912–1977) rapidly demonstrated that this hypoglycaemic effect required the presence of pancreas and was explained by stimulation of insulin secretion. He contributed to the description of a hypoglycaemic effect of several other sulphonamide compounds. He considered the diagnostic and therapeutic relevance of this class of drugs. This is a good example of a medical discovery combining a favourable local environment, serendipity and perfect experimental approach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|