Change in High-Density Lipoprotein Cholesterol and Incident Coronary Heart Disease in Apparently Healthy Male Physicians
| Autor: | Howard D. Sesso, Thomas S. Bowman, J. Michael Gaziano, Catherine Rahilly-Tierney, Luc Djoussé |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Coronary Disease Article Cohort Studies chemistry.chemical_compound High-density lipoprotein Physicians Diabetes mellitus Internal medicine medicine Humans Myocardial infarction Prospective cohort study Aged Aged 80 and over Cholesterol business.industry Proportional hazards model Cholesterol HDL Hazard ratio nutritional and metabolic diseases Middle Aged medicine.disease chemistry Multivariate Analysis Cardiology lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | The American Journal of Cardiology. 102:1663-1667 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2008.07.055 |
| Popis: | The association between change in high-density lipoprotein cholesterol (HDL-C) and risk of subsequent coronary heart disease (CHD) remains unclear. We calculated the change in HDL-C in a prospective cohort of 4501 male physicians enrolled in the Physician's Health Study I (PHS I) who had HDL-C levels measured in 1982-1983 and again approximately 14 years later. Subjects were divided into categories: those with a decrease (of -2.5 mg/dL or more), those with no change in HDL-C (change between -2.5 mg/dL and 2.5 mg/dL), those with a small increase in HDL-C of 2.5 to 12.5 mg/dL, and those with a large increase in HDL-C of ≥12.5 mg/dL. We used Cox proportional hazards to examine the association between change in HDL-C and incident CHD (confirmed acute myocardial infarction or cardiac death). Hazard ratios were adjusted for age, initial HDL-C level, diabetes mellitus, hypertension, non-HDL cholesterol, and history of cholesterol medication. Compared to subjects with a decrease in HDL-C, multivariable-adjusted hazard ratios (HR, 95% confidence interval, CI) for CHD were 0.66(0.40-1.09) in subjects with no change in HDL-C, 0.56 (0.35-0.89) for subjects with an increase in HDL-C between 2.5 mg/dL and 12.5 mg/dL, and 0.43 (0.23-0.83) for subjects with HDL-C increase of ≥12.5 mg/dL. In conclusion, our findings are consistent with an inverse, graded relation between 14-year increase in HDL-C and risk of subsequent CHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect