Influence of Algae Supplementation on the Concentration of Glutathione and the Activity of Glutathione Enzymes in the Mice Liver and Kidney
| Autor: | Iwona Stanislawska, Małgorzata Jefimow, Grażyna Świderska-Kołacz, Anna Wojciechowska, Norbert Rączka, Joanna Czerwik-Marcinkowska, Jolanta Klusek, Szymon Zmorzyński, Marek Łyp |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Antioxidant medicine.medical_treatment Kidney medicine.disease_cause Article Mice 03 medical and health sciences chemistry.chemical_compound medicine Animals oxidative stress TX341-641 Food science glutathione glutathione enzymes Diatoms algae chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply Cholesterol EPA Glutathione Malondialdehyde Eicosapentaenoic acid Freeze Drying 030104 developmental biology Liver chemistry Docosahexaenoic acid Dietary Supplements supplementation lipids (amino acids peptides and proteins) Oxidative stress Food Science Polyunsaturated fatty acid |
| Zdroj: | Nutrients Volume 13 Issue 6 Nutrients, Vol 13, Iss 1996, p 1996 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Algae are potential and natural source of long-chain polyunsaturated fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The diatom Pinnularia borealis accumulates high levels of EPA and may be considered as a source for commercial production of dietary supplements. In this study we asked the question whether diet supplementation with P. borealis may augment antioxidant defense and ameliorate risk factors for cardiovascular diseases. We fed mice (Mus musculus) with lyophilized diatom solutions of different concentrations (1%, 3%, and 5%) for 7 days. Then we measured glutathione content and the activity of glutathione redox system enzymes, total cholesterol and triacylglycerol concentrations, and malondialdehyde concentration in the liver and kidney. We found that cholesterol and triacylglycerol concentrations in the liver and kidneys were the lowest in mice who were fed with the highest concentration of Pinnularia borealis, suggesting protective properties of algae. Additionally, the lowest concentration of Pinnularia borealis was sufficient to improve antioxidant capacity. Our results suggest that P. borealis may be used as a source for dietary supplements rich in EPA, but the amount supplied to the organism should be limited. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|