Detection of heterozygous MDR1 nt230(del4) mutation in a mixed-breed dog: case report of possible doxorubicin toxicosis

Autor:	Kari V. Lunsford, Camilo Bulla, João Pessoa Araújo Júnior, Marina Mitie Monobe
Přispěvatelé:	Universidade Estadual Paulista (Unesp), Mississippi State University
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Pathology medicine.medical_specialty biology business.industry Neurotoxicity Cancer Pharmacology P-glycoprotein medicine.disease Toxicology Canine Mixed breed dog Mutation (genetic algorithm) biology.protein Medicine Doxorubicin business Gene Barrier function medicine.drug
Zdroj:	Currículo Lattes Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP
ISSN:	2230-2034
Popis:	Made available in DSpace on 2016-07-07T12:34:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2013. Added 1 bitstream(s) on 2016-07-07T12:43:35Z : No. of bitstreams: 1 ISSN2230-2034-2013-04-35-38.pdf: 217721 bytes, checksum: 09287953442e14c5ce5b8a8263d5d88e (MD5) P-glycoprotein (ABCB1), the product of the Multidrug Resistance Gene (MDR1) (ABCB1) gene, is the major multidrug transporter contributing to the barrier function of several tissues and organs, including the brain. A four base pair deletion mutation in MDR1 results in the absence of a functional form of ABCB1 and loss of its protective function. Severe intoxication with the ABCB1 substrate, such as with anticancer drugs, has been attributed to genetic lack of functional ABCB1. This mutation has been detected in more than 10 dog breeds as well as in mixed-breed dogs living in different countries. In Brazil, evaluation for this mutation is not as widely available and is rarely used by veterinarians, so drug intoxication may be underdiagnosed. This is the first report from Brazil of doxorubicin neurotoxicity in a mixed-breed dog with the MDR1 nt230(del4) mutation. Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil Mississippi State University, MS, USA Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências (IBB), Departamento de Microbiologia e Imunologia, Botucatu, SP, Brasil
Databáze:	OpenAIRE
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