Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes
| Autor: | Gustavo Brunelli Vallim, Luiz Carlos do Nascimento, Wilhan Donizete Gonçalves Nunes, Massao Ionashiro, Roni Antônio Mendes, Caroline Gaglieri, Aniele de Moura, Flávio Junior Caires, André Luiz Carneiro Soares do Nascimento |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Federal de Alfenas (UNIFAL-MG) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Evolved gas analysis Chemistry Thermal decomposition Infrared spectroscopy 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Complexometric titration 0104 chemical sciences Coordination complex Metal Thermogravimetry Complexes visual_art Differential thermal analysis visual_art.visual_art_medium Thermal behavior Antibacterial activity Physical and Theoretical Chemistry 0210 nano-technology Nuclear chemistry Norfloxacin |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2018-12-11T17:35:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-05-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordination compounds of transition metals with norfloxacin (Nor) have potential to improve its effectiveness, as already discussed for some compounds found in the literature. The complexes in the solid state were prepared by precipitation of the respective metal cation (M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)) with a norfloxacin sodium salt solution. The thermal behavior under oxidative and pyrolysis conditions was investigated employing thermogravimetry and differential thermal analysis (TG/DTG–DTA) and evolved gas analysis (EGA/TG-FTIR), and the complexes were characterized by elemental analysis (EA), EDTA complexometric titration, infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). By these results, the minimum formula was established as [M(Nor)2(H2O)2]·nH2O, where n = 3 (Ni), 2.5 (Mn Co, Zn), or 2 (Cu). The evolved gases identified during thermal decomposition of Ni and Cu complexes were ethylene, CO2 and CO for Ni; CO2 and ethane for Cu. Also, antimicrobial activity of the complexes was evaluated by in vitro susceptibility test using the agar diffusion method, and the results were compared with the uncomplexed molecule. It was found that norfloxacin complexation modifies its antibacterial activity. The activity depends on the type of metal ion and microorganism; Mn(II), Co(II) and Zn(II) complexes significantly increased activity against the tested gram-negative bacteria. Instituto de Química Universidade Estadual Paulista (UNESP) Faculdade de Ciências Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Universidade Federal de Alfenas (UNIFAL-MG) Instituto de Ciência e Tecnologia Universidade Federal de Alfenas (UNIFAL-MG) Instituto de Química Universidade Estadual Paulista (UNESP) Faculdade de Ciências Universidade Estadual Paulista (UNESP) CNPq: 421469/2016-1 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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