Antioxidants Associated With Oncogenic Human Papillomavirus Infection in Women
| Autor: | Tung-Sung Tseng, Joseph Su, Qiufan Fu, Michael E. Hagensee, Navya Nair, Martin J. J. Ronis, Jennifer E. Cameron, Yu-Hsiang Kao, Krzysztof Reiss, Hsiao-Man Chang, Hui-Yi Lin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Adolescent Genotype National Health and Nutrition Examination Survey Carcinogenesis Serum albumin Uterine Cervical Neoplasms Physiology medicine.disease_cause Antioxidants Major Articles and Brief Reports 03 medical and health sciences 0302 clinical medicine Immune system Prevalence medicine Humans Immunology and Allergy Papillomaviridae Cervical cancer biology business.industry Papillomavirus Infections HPV infection virus diseases Middle Aged Nutrition Surveys medicine.disease female genital diseases and pregnancy complications United States Oxidative Stress 030104 developmental biology Infectious Diseases Quartile 030220 oncology & carcinogenesis DNA Viral Vagina biology.protein Female business Oxidative stress |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiab148 |
| Popis: | BackgroundHuman papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed the onset of HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The association between antioxidants and oncogenic HPV remains unclear. In this study, we aim to identify antioxidants associated with vaginal HPV infection in women.MethodsThe associations between the 15 antioxidants and vaginal HPV infection status (no, low-risk [LR], and high-risk [HR] HPV) were evaluated using 11 070 women who participated in the 2003–2016 National Health and Nutrition Examination Survey (NHANES).ResultsWe identified serum albumin and 4 dietary antioxidants (vitamin A, B2, E, and folate) inversely associated with HR-HPV infection. Women with a low level of albumin (≤39 g/L) have a significantly higher risk of HR-HPV (odds ratio [OR] = 1.4, P = .009 vs >44 g/L). A Nutritional Antioxidant Score (NAS) was developed based on these 4 dietary antioxidants. The women with the lowest quartile NAS had a higher chance of HR-HPV (OR = 1.3, P = .030) and LR-HPV (OR = 1.4, P = .002) compared with the women with the highest quartile NAS.ConclusionsWe identified 5 antioxidants negatively associated with vaginal HR-HPV infection in women. Our findings provide valuable insights into understanding antioxidants’ impact on HPV carcinogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|