Lower early morning plasma cortisol levels are associated with thyroid autoimmunity in the elderly
| Autor: | George Papageorgiou, C. Mara, A. Mantzou, Maria Alevizaki, K. Terzidis, Katerina Saltiki, P. Tourli, A. Panoutsopoulos |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aging medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Thyroid Function Tests Iodide Peroxidase Thyroid function tests Dexamethasone Endocrinology Internal medicine Blood plasma Prevalence medicine Humans Glucocorticoids Aged Autoantibodies Aged 80 and over Triiodothyronine medicine.diagnostic_test business.industry Thyroiditis Autoimmune General Medicine Middle Aged Anti-thyroid autoantibodies Circadian Rhythm Dexamethasone suppression test Female business Body mass index Glucocorticoid medicine.drug |
| Zdroj: | European Journal of Endocrinology. 162:307-313 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-09-0534 |
| Popis: | ObjectivesThyroid autoimmunity decreases in the very old. We investigated whether glucocorticoid (GC) activity, which increases in old age, is involved in this process.Subjects and methodsA total of 321 ambulatory subjects (age 51–95 years, median 71, 207 female) were studied. Thyroid function tests, cortisol, glucose, insulin and biochemical parameters were measured. A modified overnight dexamethasone suppression test (0.25 mg) was performed as an index of GC sensitivity.ResultsForty subjects had positive anti-thyroid peroxidase antibodies and 36 had positive anti-thyroglobulin antibodies, while 57 had either one or the other or both thyroid autoantibodies (ThAbs) positive. Mean basal cortisol levels were significantly lower in the ThAbs (+) groups (320±125 vs 378±128 nmol/l, P=0.002). Triiodothyronine, free thyroxine, post-dexamethasone cortisol levels, C-reactive protein, homeostasis model assessment-insulin-resistance-index and body mass index did not differ between these two groups. Mean age of ThAbs (+) subjects was lower compared to the ThAbs (−) group (67.38±7.38 vs 71.64±8.57 years, P=0.001).ConclusionsReduced GC activity is associated with an increased prevalence of ThAbs positivity in older ambulatory subjects. Subjects without ThAbs in this population sample are relatively older. It is not known whether this is related to increasing GC activity with age. |
| Databáze: | OpenAIRE |
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