Risk of Preterm Delivery Associated with Prior Treatment of Cervical Precancerous Lesion according to the Depth of the Cone
| Autor: | Tito Silvio Patrelli, Michela Monica, Andrea Dall'Asta, Eleonora Mazzone, Laura Franchi, Francesca Peri, Salvatore Gizzo, Alberto Bacchi Modena, Roberto Berretta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Infertility
Adult Risk medicine.medical_specialty Article Subject medicine.medical_treatment Clinical Biochemistry Conization Uterine Cervical Neoplasms Cervix Uteri Cervical intraepithelial neoplasia Young Adult Pregnancy Risk Factors Genetics medicine Humans Molecular Biology Retrospective Studies Gynecology lcsh:R5-920 Obstetrics business.industry Biochemistry (medical) Female infertility Gestational age Retrospective cohort study General Medicine medicine.disease Cervical conization Uterine Cervical Dysplasia Treatment Outcome Premature birth Clinical Study Premature Birth Female business lcsh:Medicine (General) Infertility Female Precancerous Conditions |
| Zdroj: | Disease Markers, Vol 35, Iss 6, Pp 721-726 (2013) Disease markers |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | The aim of this study was to evaluate the impact of the surgical excisional procedures for cervical intraepithelial neoplasia (CIN) treatment both on subsequent fertility (cervical factor) and pregnancy complication (risk of spontaneous preterm delivery). We retrospectively analyzed 236 fertile women who underwent conization for CIN. We included in the study 47 patients who carried on pregnancy and delivered a viable fetus. Patients were asked about postconization pregnancies, obstetrical outcomes, and a possible diagnosis of secondary infertility caused by cervical stenosis. We evaluated the depth of surgical excision, the timing between cervical conization and subsequent pregnancies, surgical technique, and maternal age at delivery. We recorded 47 deliveries, 10 cases of preterm delivery; 8 of them were spontaneous. The depth of surgical excision showed a statistically significant inverse correlation with gestational age at birth. The risk of spontaneous preterm delivery increased when conization depth exceeded a cut-off value of 1.5 cm. Our data do not demonstrated a relation between conization and infertility due to cervical stenosis. |
| Databáze: | OpenAIRE |
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