Advances and applications of isomotive dielectrophoresis for cell analysis
Autor: | Stuart J. Williams, Mohamed Z. Rashed |
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Rok vydání: | 2020 |
Předmět: |
Electrophoresis
Computer science 010401 analytical chemistry Microfluidics Sorting Nanotechnology Cell analysis Cell Separation Equipment Design 02 engineering and technology Dielectrophoresis 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Field (computer science) 0104 chemical sciences Analytical Chemistry Unmet needs Characterization (materials science) 0210 nano-technology Throughput (business) |
Zdroj: | Analytical and Bioanalytical Chemistry. 412:3813-3833 |
ISSN: | 1618-2650 1618-2642 |
Popis: | Isomotive dielectrophoresis (isoDEP) is a unique electric field such that the gradient of the field-squared ([Formula: see text]) is constant, resulting a uniform dielectrophoretic force. The current status of isoDEP is presented in this review, and we will highlight the progress that has been achieved over the past 60 years in various avenues of isoDEP since H.A. Pohl initially described its premise. This article will discuss its applications and describe the various configurations of generating an isomotive force. Since H.A. Pohl introduced the theory of isoDEP, numerous authors have implemented isoDEP as a tool for the manipulation, sorting, separation, and characterization of polarizable particles without the need for biochemical labels or other bioengineered tagging. The growing field of microfluidics and electrokinetics has renewed interest in isoDEP, particularly for analytical characterization or separation of particles. Recent work has demonstrated that isoDEP can address some unmet needs for biomedical applications including single-cell analysis; moreover, advances in throughput as well as combining characterization and separation simultaneously will add significant value to isoDEP. |
Databáze: | OpenAIRE |
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