Efficacy of anti-influenza peptide vaccine in aged mice
| Autor: | Ruth Arnon, Tamar Ben-Yedidia, Amiela Globerson, Loya Abel |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Aging
T-Lymphocytes medicine.medical_treatment Molecular Sequence Data Chick Embryo Antibodies Viral Virus law.invention Mice Immune system law Influenza Human medicine Animals Humans Amino Acid Sequence Lung Mice Inbred BALB C Vaccines Synthetic business.industry Virology Peptide Fragments Mice Inbred C57BL Vaccination Influenza A virus Influenza Vaccines Antibody Formation Immunology Recombinant DNA Peptide vaccine Cytokines Nasal administration Viral disease business Adjuvant Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 104:11-23 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/s0047-6374(98)00045-1 |
| Popis: | Influenza infections may cause serious morbidity, as well as mortality in the elderly. In the present study we vaccinated old and young mice of two strains with three synthetic recombinant constructs (Levi and Arnon, 1995. In: Chanock, R.M. et al. (Eds.), Vaccines 95. CSHL Press, New York, pp. 311–316) and examined their capacity to eliminate a challenge of virus. Virus clearance from the lungs in the aged was very efficient, although the immune response in the aged was comparatively reduced. The data demonstrate that an intranasal administration of peptide-based anti-influenza vaccine without any adjuvant can be efficient and protective in old mice. Further studies are needed to determine whether such constructs will provide an effective vaccine for elderly human subjects. |
| Databáze: | OpenAIRE |
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