The effect of docosahexaenoic acid on apelin distribution of nervous system in the experimental mouse model of Parkinson’s disease
| Autor: | Nuray Acar, Hande Parlak, Hakan Soylu, Ayse Ozkan, Ismail Ustunel, Aysel Agar, V. Nimet İzgüt-Uysal, Sema Avci |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parkinson's disease Docosahexaenoic Acids genetic structures Central nervous system Biology Nervous System Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Parkinsonian Disorders Internal medicine medicine Animals Humans Receptor Apelin receptor Apelin Receptors MPTP food and beverages Parkinson Disease Cell Biology General Medicine medicine.disease Eicosapentaenoic acid nervous system diseases Apelin Disease Models Animal Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure Endocrinology Eicosapentaenoic Acid Gene Expression Regulation chemistry Docosahexaenoic acid lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Tissue and Cell. 56:41-51 |
| ISSN: | 0040-8166 |
| DOI: | 10.1016/j.tice.2018.12.002 |
| Popis: | Parkinson’s disease (PD) is a degenerative disorder of the human central and peripheral nervous systems. n-3 fatty acids docosahexaenoic acid (DHA, C22: 6n-3) and eicosapentaenoic acid (EPA) as well as apelin have anti-inflammatory effects in various cells. At the same time, apelin has anti-oxidative and anti-apoptotic effects. The study was conducted to determine the effect of DHA on the distribution of apelin and apelin receptor (APJ) in the central nervous system in 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine (MPTP)-induced PD model. DHA treatment decreased the return time and total down time in the Parkinson group which were measured by pole test. Besides, the ambulatory activity, distance and total locomotor activity were increased by DHA in the PD model of animals. The time mice remained on the rotating rod mile was also significantly increased by DHA treatment in MPTP injected animals. The apelin expression in the pons of mice in the Parkinson, DHA and Parkinson + DHA groups were lower compared to the Control group. When apelin and apelin receptor expressions in cerebrum were examined, there was no statistically significant difference between the groups. When apelin receptor expression in cerebellum was examined, the difference between the Control and Parkinson + DHA, Parkinson and Parkinson + DHA, DHA and Parkinson + DHA groups were statistically significant. Apelin receptor expressions in pons of the Parkinson, DHA and Parkinson + DHA groups were lower compared to the Control group. Apelin protein levels of cerebellum and pons were found to be decreased in DHA group compare with Control group. In conclusion; DHA has been implicated in the expression of the apelin receptor and has reduced the expression of APJ receptor. |
| Databáze: | OpenAIRE |
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