Growth Characteristics in individuals with Osteogenesis Imperfecta in North America - Results from a Multicenter Study
| Autor: | Allison Tam, Mahim Jain, Melanie Pepin, Jay R. Shapiro, Michaela Durigova, Eric T. Rush, Mary A. Mullins, Laura L. Tosi, Jeffrey P. Krischer, Sandesh C.S. Nagamani, Michael B. Bober, Deborah Krakow, Peter H. Byers, Brendan Lee, Peter A. Smith, Sunil Bellur, Francis H. Glorieux, Robert D. Steiner, David Cuthbertson, Frank Rauch, Cathleen L. Raggio, David R. Eyre, Tracy Hart, Eric S. Orwoll, V. Reid Sutton |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment growth Pamidronate 030209 endocrinology & metabolism Short stature Article Body Mass Index 03 medical and health sciences Young Adult 0302 clinical medicine natural history study medicine Humans Young adult Child Genetics (clinical) 2. Zero hunger Diphosphonates business.industry Body Weight weight Bisphosphonate Osteogenesis Imperfecta medicine.disease Body Height 030104 developmental biology Multicenter study Osteogenesis imperfecta Child Preschool Cohort North America Female medicine.symptom business Body mass index Natural history study height |
| Zdroj: | Genetics in medicine : official journal of the American College of Medical Genetics |
| ISSN: | 1530-0366 1098-3600 |
| Popis: | Osteogenesis imperfecta (OI) predisposes people to recurrent fractures, bone deformities, and short stature. There is a lack of large-scale systematic studies that have investigated growth parameters in OI. Using data from the Linked Clinical Research Centers, we compared height, growth velocity, weight, and body mass index (BMI) in 552 individuals with OI. Height, weight, and BMI were plotted on Centers for Disease Control and Prevention normative curves. In children, the median z-scores for height in OI types I, III, and IV were −0.66, −6.91, and −2.79, respectively. Growth velocity was diminished in OI types III and IV. The median z-score for weight in children with OI type III was −4.55. The median z-scores for BMI in children with OI types I, III, and IV were 0.10, 0.91, and 0.67, respectively. Generalized linear model analyses demonstrated that the height z-score was positively correlated with the severity of the OI subtype (P |
| Databáze: | OpenAIRE |
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