Inhibitory Effect of AL-3264, a New Antiallergic Agent, on the Prausnitz-Küstner Reaction and Leukotriene Production in Monkeys
| Autor: | Chikako Sakaki, Hideo Nakamura, Ikuhisa Yakuo, Katsumi Ishii, Kunihiko Takeyama |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Ketotifen Leukotrienes Leukotriene Production Mepyramine Pharmacology Piperazines chemistry.chemical_compound medicine Animals Skin Tests Acrylamides Leukotriene Allergens Intradermal Tests Macaca fascicularis chemistry Mechanism of action Antiallergic agent Acrylamide Histamine H1 Antagonists medicine.symptom Bronchoalveolar Lavage Fluid Histamine medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 67:263-266 |
| ISSN: | 0021-5198 |
| Popis: | To clarify the antiallergic effect and antiallergic mechanism of AL-3264 (N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide) in monkeys, its effects on the Prausnitz-Kustner (P-K) reaction, the histamine skin reaction and leukotriene production were examined. In contrast to ketotifen and mepyramine, AL-3264 inhibited the P-K reaction, which is mainly mediated by leukotriene and histamine, more clearly than the skin reaction evoked by histamine alone. AL-3264 also inhibited the leukotriene (LT) production in the broncho-alveolar cells, suggesting that the inhibition of LT production actually contributes to the antiallergic effect of AL-3264. |
| Databáze: | OpenAIRE |
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